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Anti-14-3-3eta Multiplex

Anti-14-3-3eta Multiplex is a first-in-class biomarker test for Axial Spondyloarthritis.

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What is Axial Spondyloarthritis?

Axial Spondyloarthritis (axSpA) is a chronic inflammatory disease affecting the spine and sacroiliac joints, causing pain, stiffness and joint damage.

 

Burden of Diagnostic Delay

AxSpA imposes a significant burden on patients, impacting physical function, mental health, and work productivity. Diagnosis is often delayed by 7-10 years due to the absence of reliable biomarkers, with many cases misdiagnosed as chronic low back pain. Early detection is critical for preventing long-term damage and improving patient outcomes.1

Average years diagnostic delay1

Had trouble getting out of bed2

Were affected by some form of psychological distress2

Reported difficulty finding a job due to their disease2

Anti-14-3-3eta Multiplex addresses critical gaps in patient care to improve outcomes

Streamlined Diagnostic Process

Aids in the early and accurate diagnosis of axSpA, reducing the
7-10 year average time to diagnosis.

Complementary to Imaging

Offers diagnostic support alongside traditional imaging.

Clinical Confidence

Enables evidence-based decisions, leading to more timely and appropriate treatment plans.

Improved Outcomes

Anti-14-3-3eta Multiplex aids in earlier detection and intervention of axSpA, potentially preventing long-term spinal damage.

Anti-14-3-3eta Multiplex is highly sensitive and specific for early diagnosis of axSpA

Early and Accurate Diagnosis

Anti-14-3-3eta Multiplex is highly sensitive (76%) and highly specific (74%) to enable differentiation between axSpA and chronic low back pain.3

Complementary to CRP

Combined with CRP, the test can identify 90% of axSpA patients, improving diagnostic accuracy.4

HLA-B27 Independent

Provides diagnostic value even in patients who are negative for traditional markers like HLA-B27.4

Anti-14-3-3eta Multiplex is the first and only diagnostic test for axSpA

Ordering information for providers

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Anti-14-3-3eta Multiplex is the only diagnostic test for axSpA

TECHNICAL INFORMATION FOR HEALTHCARE PROFESSIONALS

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References

References:

  1. Poddubnyy D, Garrido-Cumbrera M, Sommerfleck F, et al. POS0689. Diagnostic delay in patients included in the International Map of Axial Spondyloarthritis: associations with geographic, socio-demographic and disease-related factors. Annals of the Rheumatic Diseases. 2023;82:628-629
  2. The burden of axial spondyloarthritis: A global patient perspective. International Map of Axial Spondyloarthritis (IMAS) Report. 2024, Jan. https://asif.info/imas/imas-global-report
  3. Marotta A, Maksymowych WP, Wichuk S, Sidhu N. P54 Novel Diagnostic 14-3-3η Auto-Antibody Marker for Axial Spondyloarthritis: A Longitudinal Study. Fourteenth International Congress on Spondyloarthritides. Clin Exp Rheumatol. 2024.
  4. Marotta A, Maksymowych WP, Wichuk S, Sidhu N. POS1094 Autoantibodies to 14-3-3η in Axial Spondyloarthritis. Annals of the Rheumatic Diseases. 2024;83:892-893.

How to order a test

i

Step 1.

Register on our portal

w

Step 2.

We will contact you and finalize your account

Step 3.

You are now ready to order by requisition

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What do patients need to know?

No pretest dietary or medication restrictions before blood draw.

Testing may take a few days to be completed.

Patients with positive results should have their diagnosis confirmed by a rheumatologist.

How is the sample tested?

Provider-Patient Discussion

Routine Blood Work

Plasma-Based Testing by Luminex® in our lab

Patient Management

Understanding Anti-14-3-3eta Multiplex Test Result

Negative Test Result

A negative Anti-14-3-3eta Multiplex test result indicates a low likelihood of axSpA.

Positive Test Result

A positive Anti-14-3-3eta Multiplex test result indicates a high likelihood of axSpA, and requires assessment and confirmed diagnosis by a rheumatologist.

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What is the science behind Anti-14-3-3eta multiplex?

Anti-14-3-3eta Multiplex is a novel diagnostic test that detects autoantibodies against the normally intracellular 14-3-3eta protein, a well-established biomarker in autoimmune rheumatologic disorders.

Where do my patients get tested?

A routine blood draw may be performed at your office or through our phlebotomy partners.

Sample Test Report

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